I've come to realize that I will never be able to clear my to-be-read pile. My frequency of buying books far exceeds the rate at which I go through them. I read books much too slowly.
Perhaps I may not be able to read David Foster Wallace's Infinite Jest or James Joyce's Finnegan's Wake, but at least I have them on my shelf. I can always pretend that I've read them. I'm guessing that anything I say about these doorstops would be considered as true, since I think that not many people have actually read them.
I can always say that "Infinite Jest is a celebration of pop culture in all its wondrous facets" or that "Finnegan's Wake represents the zenith of modernist fiction."
I love my TBR pile. I consider it as my baby -- I can watch it grow through the years. It'll have periods of stunted growth (when I don't have money) and intermittent growth spurts (during book sales).